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KMID : 0942820090080020225
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Journal of Korean Brain Tumor Society
2009 Volume.8 No. 2 p.225 ~ p.229
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Malignant Transformation of Pleomorphic Xanthoastrocytoma of Cerebellum
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Yang Kyung-Hoon
Nam Do-Hyun
Kong Doo-Sik
Kim Jong-Hyun
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Abstract
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Pleomorphic xanthoastrocytoma(PXA) is a superficially located, rare glial tumor first described in 1979. It affects young patients, who often present with seizures. The tumor has a relatively favorable prognosis, but 15-20% progress to malignancy. We describe a case of PXA which was benign features at presentation, but underwent anaplastic transformation. Surgery remains the mainstay of treatment. Factors influencing clinical outcome include extent of resection, and histological features such as mitotic index, necrosis and lymphocytic infiltration. The roles of radiotherapy and chemotherapy remain undefined. We advocate lifelong follow-up and establishment of a central registry in order to further understanding of this infrequently encountered tumor.
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KEYWORD
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Pleomorphic xanthoastrocytoma, Anaplastic transformation, Cerebellum, Gamma knife, Recurrence
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